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Description

Estring (Estradiol) vaginal ring belongs to a class of medications called hormones. This medication works by replacing estrogen that is normally produced by the body. The hormone from the vaginal ring is directly absorbed through the skin of the vagina wall. It is used by women for treating vaginal dryness, itching, and burning; painful intercourse; painful urination, or the feeling of needing to urinate more often than usual that are experiencing or have experienced menopause. Estradiol vaginal ring is also prescribed for use to treat moderate to severe hot flashes and other symptoms of menopause or low amounts of estrogen.

Doctor's prescription is required to use this medicine.

Always use Estring as directed by your physician.

Follow all directions on your prescription label and read all medication guides or instruction sheets. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after inserting an Estring vaginal ring.

To use the Estring vaginal ring:

• Squeeze the sides of the Estring vaginal ring together and insert it into the vagina as far as possible (into the upper 1/3 of the vagina). You should not be able to feel the ring once it is in position. If you can feel it, use a finger to push it further into the vagina. It is not possible for the ring to go too far in or become lost.

• Estring vaginal ring is to be used only in the vagina. Use it at bedtime unless your doctor tells you otherwise. The Estring vaginal ring should remain in place for 90 days. It should then be removed and replaced by a new ring, if prescribed by your doctor. If at any time the ring falls out, rinse it with warm water and reinsert it.

• The Estring vaginal ring does not need to be removed during sexual intercourse. It should not be felt by either partner. If it is bothersome, it can be removed, rinsed with warm water, and reinserted following intercourse.

• To remove the ring, loop a finger through the ring and gently pull it from the vagina.

Cautions

Always use Estring exactly as directed by your doctor.

Before using E-string, tell your doctor or pharmacist if you are allergic to it or any other medications. Tell your doctor or pharmacist about your medical history. Tell your doctor about all the other prescription and nonprescription medications you are taking.

Do not use Estring if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

You should not use Estring if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using Estring can increase your risk of blood clots, stroke, or heart attack, or cancer of the breast, uterus, or ovaries. Estradiol should not be used to prevent heart disease, stroke, or dementia.

NOTE: This medicine is only for you. Do not share this medicine with others.

Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction to Estring: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Remove the vaginal ring and seek emergency medical attention if you have: fever with nauseavomitingdiarrheamuscle paindizziness, fainting, and/or sunburn-like skin rash. These may be signs of a life-threatening disease called toxic shock syndrome.

Call your doctor at once if you have:

  • Heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.
  • Signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.
  • Signs of a blood clot - sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs.
  • Swelling or tenderness in your stomach.
  • Jaundice (yellowing of the skin or eyes).
  • Memory problems, confusion, unusual behavior.
  • Unusual vaginal bleeding, pelvic pain.
  • A lump in your breast.
  • High levels of calcium in your blood - nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.

Common Estring side effects may include:

  • Nausea, vomiting, bloating, stomach cramps.
  • Headache.
  • Swelling in your hands or feet, weight gain.
  • Breast pain.
  • Vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

 

FAQs

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

In case of overdose, call the poison control helpline. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services.

Where should I keep my medicine?

Keep out of reach of children.

Store at room temperature.

Throw away any unused medicine after the expiration date.

What should I avoid while using Estring?

Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using Estring.

Avoid using other vaginal products without your doctor's advice.

Grapefruit and grapefruit juice may interact with estradiol and lead to unwanted side effects. Avoid the use of grapefruit products.

 

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Alida

May 28, 2025

A GREAT CHOICE! It took me several days to choose a pharmacy I felt comfortable with and, after searching for days several days, I knew I found the right Pharmacy for me. The staff was so friendly, all my questions were answered to my liking, and when I called I got a real person every time and their attention to every person and detail made me very happy. I placed my first order and just received it. It arrived 14 days after I ordered it and I live in New York City! How’s that for service? I gave a 5 star review, but it should be a 10!!

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May 18, 2025

I am so impressed with Canadian Pharmacy Service. They are professional, friendly, knowledgeable and helpful. I received my first order recently and it was not only on time, but the package was like a present. I will be spreading the word about this wonderful Pharmacy.

Albert V

February 25, 2025

Your services were recommended by a relative. They did much research comparing various companies wisely selecting your organization. My experience has been very positive. Your diligent staff has been prompt, knowledgeable and professional in handling my inquiries and concerns while establishing initial services. Look forward to continued excellent service.

Molly

February 14, 2025

I found Canadian Pharmacy Service after my husband was prescribed an expensive drug. After much research I called and someone walked me through the process. It was really much easier than I thought. Everyone is very professional and explained everything. They call to see if you are ready for your next shipment and will even call your doctor when your prescription needs to be refilled. Would definitely recommend.

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October 26, 2022

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October 13, 2022

You have always been exemplary in service.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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