Clobex Lotion treats the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various scalp and skin conditions, including psoriasis and eczema. Clobetasol is in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the Clobex Lotion exactly as directed.

Wash your hands before and after using Clobex Lotion unless you use the medicine to treat the skin on your hands.

Apply a thin layer of the medicine to the affected skin and rub it in gently. Do not apply for this medicine over a large area of your skin unless your doctor has told you to.

Do not cover the treated skin area with a bandage or other covering unless your doctor tells you to. Covering treated areas can increase the amount of medicine absorbed through your skin and may cause harmful effects.

This medicine is for short-term use only (2 weeks or up to 4 weeks for scalp psoriasis). 

Call your doctor if your symptoms do not improve or if they get worse.

Before using Clobex Lotion, tell your doctor and pharmacist:

• If you are allergic to clobetasol, other medications, or any ingredients in clobetasol topical products,
• You are taking prescription and nonprescription medications, vitamins, and nutritional supplements or plan to take them. 
• Be sure to mention the following: other corticosteroid medications and other topical medications.
• If you are having surgery, including dental surgery, infection, skin problems, or have ever had diabetes, Cushing's syndrome or liver disease.
• If you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using clobetasol topical, call your doctor.

Clobex may cause serious side effects. Call your doctor at once if you have the following:

• Worsening your skin condition;
• Redness, warmth, swelling, oozing, or severe irritation of any treated skin;
• Blurred vision, tunnel vision, eye pain, or seeing halos around lights;
• High blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
• Possible signs of absorbing this medicine through your skin--weight gain in your face and shoulders, slow wound healing, skin discoloration, thinning skin, increased body hair, tiredness, mood changes, menstrual changes, and sexual changes.

Common side effects of Clobex may include:

• Burning, itching, swelling, or irritation of treated skin;
• Dry or cracking skin;
• Redness or crusting around your hair follicles;
• Spider veins;
• Stretch marks, thinning skin;
• Rash or hives;
• Acne; or
• Temporary hair loss.

These are not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects.

What is Clobex Lotion used to treat?

Clobex Lotion is a strong topical corticosteroid used to treat various skin conditions, including plaque psoriasis. 

Does Clobex Lotion cause weight gain?

Clobex lotion shouldn't cause weight gain if used for a short time. Using this medication for a long period can cause a problem called Cushing's syndrome. Signs of this problem include weight gain, pink or purple stretch marks, thin skin, and easy bruising.

What are the possible side effects of Clobex Lotion?

Burning, stinging, itching, irritation, dryness, or redness may occur when this medication is first applied to the skin.