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Compazine (Prochlorperazine) belongs to a class of medications called conventional antipsychotics. This medication works by affecting the chemical balance in the brain. Prochlorperazine helps treating symptoms of psychotic disorders such as excessive anxiety, tension, confusion, delusions, and agitation. Prochlorperazine is also used for controlling severe nausea and vomiting.

Doctor's prescription is required to use this medicine.

Always take Prochlorperazine as directed by your physician.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Ask your doctor if you have any questions.

Prochlorperazine comes as a tablet to take by mouth and as a suppository to place in the rectum. Prochlorperazine tablets are usually taken three to four times a day by adults and are usually given to children one to three times a day. Prochlorperazine suppositories are usually inserted twice a day. Use prochlorperazine at around the same time(s) every day. Do not stop using prochlorperazine without talking to your doctor. If you suddenly stop using prochlorperazine, you may experience withdrawal symptoms such as nausea, vomiting, dizziness, and shakiness.

Do not take this medicine in larger or smaller amounts or for longer than recommended.


Always take Prochlorperazine exactly as directed by your doctor.

Before using Prochlorperazine, tell your doctor or pharmacist if you are allergic to it or any other medications. Tell your doctor or pharmacist about your medical history. Tell your doctor about all the other prescription and nonprescription medications you are taking.

Do not take this medicine within 2 hours of taking antacids or medicine for diarrhea. Taking these products too close together may make this medicine less effective.

Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS).

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

NOTE: This medicine is only for you. Do not share this medicine with others.

Side Effects

Contact your doctor if you experience these side effects and they are severe or bothersome.

  • Changes in menstrual period
  • Constipation (mild)
  • Decreased appetite
  • Decreased sexual ability or interest
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Fatigue
  • Headache
  • Nasal congestion
  • Nausea
  • Sweating
  • Swelling or pain in breasts
  • Trouble sleeping
  • Urinary incontinence
  • Vomiting
  • Watering of mouth
  • Weight changes


Check with your doctor as soon as possible if any of the following side effects occur:

  • Agitation
  • Bizarre dreams
  • Changes in ability to move
    • inability to move eyes
    • increased blinking or spasms of eyelid
    • lip smacking or puckering
    • loss of balance control
    • restlessness or need to keep moving
    • shuffling walk
    • stiffness of arms or legs
    • trembling and shaking of hands and fingers
  • Changes in blood pressure
  • Constipation (severe)
  • Dizziness when rising from sitting or lying position
  • Fast, slow, or irregular heartbeat
  • Flu-like symptoms (sudden lack of energy, fever, cough, sore throat)
  • Increased blood pressure
  • Mask-like face (reduced facial expression)
  • Secretion of milk (unusual)
  • Signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • Signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
  • Signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • Symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
  • Skin rash
  • Sunburn (severe)
  • Swelling hands, feet, ankles
  • Symptoms of urinary retention such as decrease in amount of urine, or difficult or painful urination
  • Vision changes (e.g., blurred vision, changes in colour vision, or difficulty seeing at night)
  • Trouble breathing, speaking, or swallowing


Stop taking the medication and seek immediate medical attention if any of the following occur:

  • Fainting
  • Nervous system problems (e.g., drooling, upward eye rolling movement, difficulty moving how and when you want, severe muscle stiffness, trembling)
  • Prolonged, painful, inappropriate erection of the penis
  • Seizures
  • Signs of a blood clot in the arm or leg (tenderness, pain, swelling, warmth, or redness in the arm or leg) or lungs (difficulty breathing, sharp chest pain that is worst when breathing in, coughing, coughing up blood, sweating, or passing out)
  • Signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • Symptoms of neuroleptic malignant syndrome (e.g., high fever, sweating, stiff muscles, fast heartbeat, fast breathing, feeling confused, drowsy or agitated)
  • Trouble speaking or swallowing

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.


What happens if I miss a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What happens if I overdose?

In case of overdose call the Poison Help line. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services

Where should I keep my medicine?

Keep out of reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Throw away any unused medicine after the expiration date.

What should I avoid while taking this medication?

This medicine may cause drowsiness, trouble with thinking, or trouble with controlling body movements. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you.


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