Invokana (Canagliflozin) belongs to a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. Invokana (Canagliflozin) helps treating type 2 diabetes by helping kidneys to remove glucose (blood sugar) from bloodstream. This medication could be paired with diet and exercise to form a diabetes treatment program that helps improving blood sugar levels. This medication may also help reducing the risk of heart attack, stroke, or death in people with type 2 diabetes and established cardiovascular disease. Invokana (Canagliflozin) also reduces risk of end stage kidney disease (ESKD), worsening of kidney function, cardiovascular death, and hospitalization for heart failure in people with diabetic kidney disease and type 2 diabetes.

Doctor's prescription is required to use this medicine.

Always take Invokana (Canagliflozin) as directed by your physician.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Ask your doctor if you have any questions.

Invokana (Canagliflozin) comes as a tablet to take by mouth. It is usually taken once a day before breakfast or the first main meal of the day. Take Invokana at around the same time every day. Do not stop taking this medication without talking to your doctor.

Do not take more or less of it or take it more often than prescribed by your doctor.

Always use Invokana (Canagliflozin) exactly as directed by your doctor.

Before using Invokana, tell your doctor or pharmacist if you are allergic to it or any other medications. Tell your doctor or pharmacist about your medical history. Tell your doctor about all the other prescription and nonprescription medications you are taking.

You should not use Invokana if you are allergic to canagliflozin, or if you have severe kidney disease (or if you are on dialysis).

To make sure this medicine is safe for you, tell your doctor if you have ever had:

• heart problems;

• a diabetic foot ulcer or amputation;

• circulation problems or nerve problems in your legs or feet;

• kidney disease;

• liver disease;

• bladder infections or other urination problems;

• a pancreas disorder;

• diabetic ketoacidosis; or

• if you are on a low salt diet.

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking canagliflozin, call your doctor.

You should not use canagliflozin during the second or third trimester of pregnancy.

Invokana is not approved for use by anyone younger than 18 years old.

NOTE: This medicine is only for you. Do not share this medicine with others.

Tell your doctor if any of these symptoms are severe or do not go away:

• Urinating a lot, including at night
• Increased thirst
• Constipation
• Dry mouth

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

• Frequent, urgent, burning, or painful urination
• Decrease in amount of urine
• Urine that is cloudy, red, pink, or brown
• Strong smelling urine
• Pelvic or rectal pain
• (In women) Vaginal odor, white or yellowish vaginal discharge (may be lumpy or look like cottage cheese), or vaginal itching
• (In men) Redness, itching, or swelling of the penis; rash on the penis; foul smelling discharge from the penis; or pain in the skin around the penis
• Feeling tired, weak, or uncomfortable; along with a fever and pain, tenderness, redness, and swelling of the genitals or the area between the genitals and the rectum

If you experience any of the following symptoms, stop taking canagliflozin and call your doctor immediately or get emergency medical treatment:

• Rash
• Hives
• Itching
• Difficulty swallowing
• Swelling of the face, throat, tongue, lips, mouth, or eyes
• Hoarseness

If you experience any of the following symptoms of ketoacidosis, stop taking canagliflozin and call your doctor immediately or get emergency medical treatment. If possible, check for ketones in your urine if you have these symptoms, even if your blood sugar is less than 250 mg/dL:

• Nausea
• Vomiting
• Stomach-area pain
• Tiredness
• Difficulty breathing

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

What happens if I miss a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What happens if I overdose?

In case of an overdose, seek emergency medical attention or call the Poison Help line.

Where should I keep my medicine?

Keep out of reach of children.

Store the medicine at room temperature.

Throw away any unused medicine after the expiration date.

What should I avoid while taking this medication?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.