Rybelsus (semaglutide) is an oral medication that belongs to a class of drugs called GLP-1 receptor agonists. By mimicking the actions of the natural hormone GLP-1, Rybelsus helps regulate blood sugar levels in individuals diagnosed with type 2 diabetes mellitus. To maximize the effects of Rybelsus, it’s important to take it alongside proper diet and exercise. [1] 

1. Take Rybelsus exactly as prescribed by your healthcare provider.
2. Swallow the tablet with a maximum of 4 ounces of water at least 30 minutes before the first oral medications, food, and drink of the day. 
3. Do not chew, crush, or cut the tablet.
4. If you forget to take a dose, skip the missed dose, and resume your regular dosing the following day.
5. It is important to maintain a healthy lifestyle, including a balanced diet and regular exercise, alongside Rybelsus for optimal results. [1]

Before starting Rybelsus, consult with your physician about your medical history, including any instances of pancreatitis or diabetic retinopathy. Also, inform your healthcare provider about all the medications you are taking, as they may interact with Rybelsus. 

Do not take Rybelsus if you are planning a pregnancy in the next two months, are currently pregnant, or are breastfeeding. [1]

Common side effects include:

• Nausea
• Abdominal pain
• Diarrhea
• Decreased appetite
• Vomiting
• Constipation [1]

Serious side effects may occur in rare instances:

• Pancreatitis 
• Diabetic retinopathy
• Hypoglycemia
• Acute Kidney Injury
• Hypersensitivity [1]

If you experience any serious or persistent side effects, please contact your healthcare provider so they can provide you with the best course of action.

What if I miss a dose?

If you miss a dose of Rybelsus, skip the missed dose for that day. Continue with your regular dosing schedule the next day. [1]

How should I store Rybelsus?

Rybelsus should be stored in a dry place at room temperature (68^oF -77^oF). 

Tablets should be stored inside the Rybelsus bottle, not in a pill organizer or external storage. The blue Rybelsus bottle cap contains a drying agent that protects the tablets from moisture. [2]

What happens if I don’t take Rybelsus on an empty stomach?

If Rybelsus is not taken on an empty stomach, or if you wait less than 30 minutes to consume food or beverages after taking Rybelsus, the absorption of the medication will decrease, and its effects will lessen. Therefore, adhering to the recommended guidelines is crucial to ensure the maximum benefits of Rybelsus are achieved. [1]

How often do I need to take Rybelsus?

Rybelsus should be taken once a day, at the same time every day. To achieve maximum benefits from Rybelsus, take Rybelsus on an empty stomach. Avoid eating, drinking, and taking other oral medications for at least 30 minutes after taking Rybelsus. A sip of water up to 4 ounces is allowed to assist in swallowing the tablet. [1]